45 resultados para FLEXURAL PSORIASIS

em Deakin Research Online - Australia


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Fiber buckling behavior is associated with fabric-evoked prickle, which affects clothing comfort and aesthetics. In this paper, the flexural buckling behavior of irregular or nonuniform fibers is studied using the finite element method (FEM). Fiber dimensional irregularities are simulated with sine waves of different magnitude, frequency, and initial phase. The critical buckling loads of the simulated fibers are then calculated from the FE model. The results indicate that increasing the level of irregularity will decrease the critical buckling load of fibers, but the effect of the frequency and initial phase of irregularity on fiber buckling behavior is complicated and is affected by fiber diameter and effective length.

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The compressive and flexural properties of hemp fiber reinforced concretes (FRC) were examined in this paper. Natural hemp fiber was mixed using dry and wet mixing methods to fabricate the FRC. Mechanical properties of the FRC were investigated. The main factors affecting compressive and flexural properties of the FRC materials were evaluated with an orthogonal test design. Fiber content by weight has the largest effect. The method for casting hemp FRC has been optimised. Under the optimum conditions, compressive strength increased by 4 %, flexural strength increased by 9 %, flexural toughness increased by 144 %, and flexural toughness index increased by 214 %.

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This study has examined the flexural properties of natural and chemically modified coir fiber reinforced cementitious composites (CFRCC). Coir fibers of two different average lengths were used, and the longer coir fibers were also treated with a 1 % NaOH solution for comparison. The fibers were combined with cementitious materials and chemical agents (dispersant, defoamer or wetting agent) to form CFRCC. The flexural properties of the composites, including elastic stress, flexural strength, toughness and toughness index, were measured. The effects of fiber treatments, addition of chemical agents and accelerated ageing of composites on the composites’ flexural properties were examined. The results showed that the CFRCC samples were 5–12 % lighter than the conventional mortar, and that the addition of coir fibers improved the flexural strength of the CFRCC materials. Toughness and toughness index, which were associated with the work of fracture, were increased more than ten times. For the alkalized long coir fiber composites, a higher immediate and long-term toughness index was achieved. SEM microstructure images revealed improved physicochemical bonding in the treated CFRCC.

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The free flexural vibration of symmetric honeycomb sandwich panel with 4 sides simply supported is analyzed by CPT (classical plate theory), FSDPT (first-order shear deformation plate theory) and TSDPT (third-order shear deformation plate theory). In the analysis the honeycomb core of cells is regarded equivalently as a layer of orthotropic material whose equivalent elastic parameters are determined by the modified Gibson's formula to deduce the equation of natural frequency of the sandwich panel. As shown by an example, the calculation of natural frequency of an aluminum honeycomb panel by use of TSDPT is higher accuracy than using either CPT or FSDPT.

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This paper presents a summary of the evidence review group (ERG) report into the clinical effectiveness and cost-effectiveness of ustekinumab for the treatment of moderate to severe psoriasis based upon a review of the manufacturer's submission to the National Institute for Health and Clinical Excellence (NICE) as part of the single technology appraisal (STA) process. The submission's main evidence came from three randomised controlled trials (RCTs), of reasonable methodological quality and measuring a range of clinically relevant outcomes. Higher proportions of participants treated with ustekinumab (45 mg and 90 mg) than with placebo or etanercept achieved an improvement on the Psoriasis Area and Severity Index (PASI) of at least 75% (PASI 75) after 12 weeks. There were also statistically significant differences in favour of ustekinumab over placebo for PASI 50 and PASI 90 results, and for ustekinumab over etanercept for PASI 90 results. A weight-based subgroup dosing analysis for each trial was presented, but the methodology was poorly described and no statistical analysis to support the chosen weight threshold was presented. The manufacturer carried out a mixed treatment comparison (MTC); however, the appropriateness of some of the methodological aspects of the MTC is uncertain. The incidence of adverse events was similar between groups at 12 weeks and withdrawals due to adverse events were low and less frequent in the ustekinumab than in the placebo or etanercept groups; however, statistical comparisons were not reported. The manufacturer's economic model of treatments for psoriasis compared ustekinumab with other biological therapies. The model used a reasonable approach; however, it is not clear whether the clinical effectiveness estimates from the subgroup analysis, used in the base-case analysis, were methodologically appropriate. The base-case incremental cost-effectiveness ratio for ustekinumab versus supportive care was 29,587 pounds per quality-adjusted life-year (QALY). In one-way sensitivity analysis the model was most sensitive to the number of hospital days associated with supportive care, the cost estimate for intermittent etanercept 25 mg and the utility scores used. In the ERG's scenario analysis the model was most sensitive to the price of ustekinumab 90 mg, the proportion of patients with baseline weight > 100 kg and the relative risk of intermittent versus continuous etanercept 25 mg. In the ERG's probabilistic sensitivity analysis ustekinumab had the highest probability of being cost-effective at conventional NICE thresholds, assuming the same price for the 45-mg and 90-mg doses; however, doubling the price of ustekinumab 90 mg resulted in ustekinumab no longer dominating the comparators. In conclusion, the clinical effectiveness and cost-effectiveness of ustekinumab in relation to other drugs in this class is uncertain. Provisional NICE guidance issued as a result of the STA states that ustekinumab is recommended as a treatment option for adults with plaque psoriasis when a number of criteria are met. Final guidance is anticipated in September 2009.

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The aim of this study was to investigate the impact of climate therapy on self-management in people with psoriasis. This was a prospective study of 254 adults with chronic psoriasis who participated in a 3-week climate therapy (CT) programme. The 8-scale Health Education Impact Questionnaire (heiQ) was completed at baseline, after 3 weeks of CT, and 3 months later. Change was assessed using paired sample t-tests mean (95% confidence interval) change scores (range 1-4). All heiQ scales showed statistically significant improvement after 3 weeks of CT. The greatest improvement was in Health-directed activity, followed by Emotional distress, and Skill and technique acquisition. At the 3-month follow-up, only the Emotional distress scale remained improved. In addition, disease severity (self-administered PASI; SAPASI) improved significantly from before CT to 3 weeks and 3 months after CT. This study suggests that CT provides a range of benefits that are important to people with psoriasis, particularly in the short term. A challenge is how to achieve long-term benefits.

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Rapid Prototyping Techniques (RPT) have evolved over the last decade. Novel RP techniques are being developed to improve the overall properties of parts manufactured using RPT. One such technique is the Curved layer fused deposition modeling (CLFDM) which has been developed based on the conventional Fused Deposition Modeling (FDM) technique. The CLFDM technique has gained significant amount of attention as a result of its advantages such as increased flexural strength, reduction of the stair-stepping effect and the reduction in the number of layers, especially for thin shell-like structures. This paper studies the effects of fill gap (FG) on flexural strength and bead dimension, middle-plane cross section profiles and the fracture surface and compares the results to parts made using the traditional planar layer-by-layer approach. Also, in the end some meaningful and interesting future study areas both in hardware design and software development for the CLFDM are proposed.

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Round timbers are extensively used as utility poles in Australia for electricity distribution and communication. Lack of information on their conditions results in great difficulties on asset management for industries. Despite the development of various non-destructive testing (NDT) techniques for evaluating the condition of piles, few NDTs are reported for applications on timber poles. This paper addresses challenges and issues on development of NDTs for condition assessment and embedded length of timber poles. For this paper, it is mainly focusing on determining the embedded length of the pole considering loss of the sufficient embedment length is a main factor compromising capacity and safety of timber poles. Since it is impractical for generating longitudinal waves by impacting from the top of poles, utilizing flexural wave from side impact on poles becomes attractive. However, the flexural wave is known by its highly dispersive nature. In this paper, one dimensional wave theory, guided wave theory and advanced signal processing techniques have been introduced in order to provide a solution for the problem. Two signal processing techniques, namely short kernel method and continuous wavelet transform, have been investigated for processing flexural wave signals to evaluate wave velocity and embedment length of timber poles in service.

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Low strain integrity testing is commonly used to assess the in situ condition of the poles or piles. For poles, it is important to calculate the embedment length and location of damage which is highly influenced by the accurate determination of the wave velocity. In general, depending on impact location and orientation, both longitudinal and bending waves may generate inside the pole, and these two waves have very distinct characteristics and wave velocity. These differences are even more prominent in the low frequency which is usually induced in the low strain non-destructive testing. Consequently, it will be useful if these two waves can be separated for the condition assessment of the poles. In this paper, a numerical analysis is performed on a pole considering that both waves are generated, and a method is proposed to differentiate these two waves based on an appropriate sensor arrangement that includes the location and the orientation of the sensors. Continuous wavelet transform is applied on the numerical signal to calculate the phase velocity of the waves and compared with analytical phase velocity curves. From the results, it can be seen that appropriate location and orientation of the sensors can separate the longitudinal and flexural waves as they match significantly well with the corresponding analytical phase velocity curves of these two waves.

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This research is concerned with the mechanical and physical properties of hemp fibre reinforced concrete (HFRC). An experimental program was developed based on the statistical method of fractional factors design. The variables for the experimental study were: (1) mixing method; (2) fibre content by weight; (3) aggregate size; and (4) fibre length. Their effects on the compressive and flexural performance of HFRC composites were investigated. The specific gravity and water absorption ratio of HFRC were also studied. The results indicate that the compressive and flexural properties can be modelled using a simple empirical linear expression based on statistical analysis and regression, and that hemp fibre content (by weight) is the critical factor affecting the compressive and flexural properties of HFRC.

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The Middle Permian Wandrawandian Siltstone at Warden Head near Ulladulla in the southern Sydney Basin is dominated by fossiliferous siltstone and mudstone, with a large amount of dropstones (lonestones) and some pebbly sandstone beds. Two general types of deposits are recognised from the cliff succession in view of the timing and mechanism of their formation. One is represented by the background (or primary) deposits of offshore to slope environments with abundant dropstones of glacial marine origin. This facies occurs throughout the cliff sections at Warden Head. The second type is distinguished by secondary, soft-sediment deformational deposits and structures of the primary (background) deposits, and comprises three successive layers of sandy mudstone dikes. In the second type of deposit, metre scale, laterally extensive syn-depositional slump deformation structures occur extensively in the middle part of the Wandrawandian Siltstone. The deformation structures vary in morphology and pattern, including large-scale complex-type folds, flexural stratification, concave-up structures, small-magnitude -faults accompanied by folding and brecciation. The slumps and associated syn-depositional structures are herein attributed to penecontemporaneous deformations of soft sediments (mostly mud and silty mud), formed as a result of mass movement of unconsolidated and/or semi-consolidated substrate following earthquake events. The occurrence of the earthquake event deposits (or seismites) at Warden Head supports the current view that the Sydney Basin was located in a back-arc setting near the New England magmatic arc on an active continental margin during the Middle Permian, and the timing of the earthquake events is here interpreted to indicate the onset of the Hunter Bowen Orogeny in the southern Sydney Basin.

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‘Melding’ is a novel in situ method for joining thermosetting composite structures, without the need of adhesives. Laminate joining is achieved using uncrosslinked resin matrix of the pre-preg. This study used Hexply914C pre-preg material to characterize melded CFRP structures produced using the melding method. A designated area of a laminate was maintained at temperatures below 40 °C retaining uncured (B-staged) material, while the remainder of the laminate was cured at 175 °C. After a 2.5 h cure cycle, the cured region showed a high degree of cure (0.88) and glass transition temperature (176 °C). The uncured area of the same laminate was cured in a second stage, simulating an in situ melded joint. By controlling the temperature and duration of the intermediate dwell and affecting minimum viscosity values prior to final cure, low values of porosity (<0.5%) were achieved. The mechanical properties of the resulting joint were consistent throughout the melded laminate. Flexural strength (1600 MPa), flexural modulus (100–105 MPa) and short beam strength (105–115 MPa) values observed where equivalent or greater than those found in the recommended autoclave cured control specimens. After the entire laminate was post cured, glass transition temperatures of 230 °C (peak tan δ) were observed in all areas of the laminate.